Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106
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چکیده
منابع مشابه
Peripheral benzodiazepine receptors in patients with chronic schizophrenia: a PET study with [11C]DAA1106.
Inflammatory/immunological process and glial contribution are suggested in the pathophysiology of schizophrenia. We investigated peripheral benzodiazepine receptors in brains of patients with chronic schizophrenia, which were reported to be located on mitochondria of glial cells, using [11C]DAA1106 with positron emission tomography. Fourteen patients and 14 age- and sex-matched normal controls ...
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Viruses mercilessly exploit their host cells to guarantee their own proliferation and propagation. To achieve this goal, many viruses suppress the apoptotic program, thereby avoiding premature death of the host cell. Indeed, apopto-sis of infected cells may be considered as a pristine defense against infectious pathogens, as illustrated by a simple Gedankenexperiment : if all host cells died im...
متن کاملEnigma of the peripheral benzodiazepine receptor.
Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel (M.G.); Department of Pharmacology (M.G., I.B., R.S., L.V.) and Laboratory for Research in Anesthesia, Pain and Neuroscience (Y.K.), The Bruce Rappaport Faculty of Medicine, TechnionIsrael Institute of Technology, Haifa, Israel; Department of Anesthesiology, Ha’Emek Medical Center, Afula, Israel (Y.K.); Endocrinology...
متن کاملDesign, Synthesis and Pharmacological Evaluation of Novel 2-[2-(2-Chlorophenoxy) phenyl]-1,3,4-oxadiazole Derivatives as Benzodiazepine Receptor Agonists
New derivatives of 2-[2-(2-Chlorophenoxy)phenyl]-1,3,4-oxadiazole as candidates for agonistic effect on benzodiazepine receptors were synthesized. Conformational analysis and superimposition of energy minima conformers of the novel compounds on estazolam, a known benzodiazepine agonist, revealed that the main proposed benzodiazepine pharmacophores were well matched. In pharmacological eval...
متن کاملDesign, Synthesis and Pharmacological Evaluation of Novel 2-[2-(2-Chlorophenoxy) phenyl]-1,3,4-oxadiazole Derivatives as Benzodiazepine Receptor Agonists
New derivatives of 2-[2-(2-Chlorophenoxy)phenyl]-1,3,4-oxadiazole as candidates for agonistic effect on benzodiazepine receptors were synthesized. Conformational analysis and superimposition of energy minima conformers of the novel compounds on estazolam, a known benzodiazepine agonist, revealed that the main proposed benzodiazepine pharmacophores were well matched. In pharmacological eval...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1999
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)34953-4